Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, 2800 Medical Building, 2800 Chicago Avenue South, Suite 300, Minneapolis, MN, USA.
Br J Cancer. 2011 May 10;104(10):1619-27. doi: 10.1038/bjc.2011.112. Epub 2011 Apr 5.
Growth differentiation factor 15 (GDF15) belongs to the transforming growth factor beta superfamily and has been associated with activation of the p53 pathway in human cancer. The aim of this study was to assess the prognostic value of GDF15 in patients with colorectal cancer (CRC).
Immunohistochemistry and tissue microarrays were used to analyse GDF15 protein expression in 320 patients with CRC. In a subgroup of 60 patients, the level of GDF15 protein in plasma was also measured using a solid-phase proximity ligation assay.
Patients with CRC with moderate to high intensity of GDF15 immunostaining had a higher recurrence rate compared with patients with no or low intensity in all stages (stages I-III) (HR, 3.9; 95% CI, 1.16-13.15) and in stage III (HR, 10.32; 95% CI, 1.15-92.51). Patients with high plasma levels of GDF15 had statistically shorter time to recurrence (P=0.041) and reduced overall survival (P=0.002).
Growth differentiation factor 15 serves as a negative prognostic marker in CRC. High expression of GDF15 in tumour tissue and high plasma levels correlate with an increased risk of recurrence and reduced overall survival.
生长分化因子 15（GDF15）属于转化生长因子β超家族，与人类癌症中 p53 通路的激活有关。本研究旨在评估 GDF15 在结直肠癌（CRC）患者中的预后价值。
使用免疫组织化学和组织微阵列分析 320 例 CRC 患者的 GDF15 蛋白表达。在 60 例患者的亚组中，还使用固相邻近连接测定法测量了血浆中 GDF15 蛋白的水平。
在所有分期（I-III 期）（HR，3.9；95%CI，1.16-13.15）和 III 期（HR，10.32；95%CI，1.15-92.51）中，GDF15 免疫染色强度为中高强度的 CRC 患者的复发率高于无或低强度的患者。GDF15 血浆水平较高的患者复发时间明显缩短（P=0.041），总生存期缩短（P=0.002）。
生长分化因子 15 是 CRC 的负预后标志物。肿瘤组织中 GDF15 表达高和血浆水平高与复发风险增加和总生存期缩短相关。
