Wang Jiang, Luo Lan-Zhu, Liang Dao-Miao, Guo Chao, Huang Zhi-Hong, Jian Xiao-Hong, Wen Jie
Children Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China.
Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China.
World J Clin Cases. 2023 Aug 16;11(23):5416-5429. doi: 10.12998/wjcc.v11.i23.5416.
Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.
肝细胞癌（HCC）是全球最常见的肿瘤之一，也是癌症相关死亡的主要原因。HCC的进展和转移与线粒体代谢改变密切相关，包括线粒体应激反应。线粒体因子是响应线粒体应激而产生和分泌的可溶性蛋白质，发挥着重要的免疫调节作用。免疫疗法已成为HCC的关键治疗选择。然而，治疗的积极反应通常取决于肿瘤细胞与肿瘤微环境中免疫调节的相互作用。因此，探索线粒体因子在HCC中的具体免疫调节机制对于提高免疫治疗效果至关重要。本研究全面概述了HCC与免疫微环境之间的关联，并强调了在理解线粒体功能对维持肝功能的参与方面的最新进展。此外，还对线粒体因子介导的HCC免疫调节进行了系统综述。最后，对线粒体因子在HCC中的潜在诊断和治疗作用进行了展望和总结。线粒体因子研究的最新进展代表了线粒体治疗的新前景。考虑到线粒体因子调节免疫功能的潜力，将其作为相关分子靶点进行研究有望为HCC的诊断和治疗带来巨大希望。
