免疫突触：线粒体形态很重要。
Immune synapses: mitochondrial morphology matters.
机构信息
Department of Biophysics, Saarland University, Homburg, Germany.
出版信息
EMBO J. 2011 Apr 6;30(7):1187-9. doi: 10.1038/emboj.2011.72.
Abstract
EMBO J 30 7, 1238–1250 (2011); published online February 15 2011 Proper positioning of mitochondria is critical for cellular function. Mitochondria localization close to synapses regulates signalling at neuronal and immune synapses (ISs). Vice versa, synapses influence activity, motility and the fusion/fission balance of close-by mitochondria. In this issue of , Baixauli et al (2011) identify a role for the mitochondrial fission factor dynamin-related protein 1 (DRP1) at the IS. DRP1 not only controls mitochondrial fission but also mitochondrial positioning to the IS, thereby modulating IS formation and downstream signalling.
摘要
EMBO J 30 7, 1238–1250 (2011); published online February 15 2011 线粒体的正确定位对于细胞功能至关重要。线粒体定位于突触附近可调节神经元和免疫突触（IS）的信号转导。反之，突触会影响附近线粒体的活性、运动和融合/裂变平衡。在本期的 中，Baixauli 等人（2011）确定了线粒体裂变因子相关蛋白 1（DRP1）在 IS 中的作用。DRP1 不仅控制线粒体裂变，还控制线粒体向 IS 的定位，从而调节 IS 的形成和下游信号转导。
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