Hansen A K, Svendsen O, Møllegaard-Hansen K E
Møllegaard Breeding Center, Ejby, Denmark.
Z Versuchstierkd. 1990;33(4):163-9.
Characteristics in connection with the presence of Bacillus piliformis in the barrier-protected animal rooms of a breeding centre for laboratory rats are discussed. The incidence of antibodies against B. piliformis in IFA test is high -77.8% for the total breeding centre. Clinical and pathological changes are, however, rare and mainly connected with certain rat strains. Immunosuppression with prednisolone and subsequent histopathological tests of liver sections indicate that rats with MHC-type RT1.A-u have an increased risk of developing Tyzzer's disease, while RT1.A-1-carriers seem to be resistant to this disease.
讨论了在一个实验大鼠繁育中心的屏障保护动物房内与梨形芽孢杆菌存在相关的特征。间接免疫荧光试验中针对梨形芽孢杆菌的抗体发生率很高——整个繁育中心为77.8%。然而，临床和病理变化很少见，且主要与某些大鼠品系有关。用泼尼松龙进行免疫抑制并随后对肝脏切片进行组织病理学检查表明，具有MHC型RT1.A-u的大鼠患泰泽氏病的风险增加，而携带RT1.A-1的大鼠似乎对这种疾病具有抗性。
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