Durand-Dubief Mickaël, Svensson J Peter, Persson Jenna, Ekwall Karl
Chromatin and Gene Expression; Babraham Institute; Babraham, Cambridge, UK.
Transcription. 2011 Mar;2(2):66-70. doi: 10.4161/trns.2.2.14411.
In eukaryotes transcription is complicated by the DNA being packed in nucleosomes and by supercoils induced by opening of the DNA double helix during elongation. Here we discuss our recent genome-wide work regarding topoisomerases and their role in chromatin remodeling during the transcription cycle and we report a novel function for topoisomerases in transcription termination.
在真核生物中,转录过程较为复杂,因为DNA被包装在核小体中,并且在延伸过程中DNA双螺旋的打开会诱导超螺旋的产生。在此,我们讨论了我们最近在全基因组范围内关于拓扑异构酶及其在转录周期中染色质重塑作用的研究工作,并报告了拓扑异构酶在转录终止中的新功能。