Departments of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
Neurol Sci. 2011 Oct;32(5):795-9. doi: 10.1007/s10072-011-0564-x. Epub 2011 Apr 6.
Neuromyelitis optica (NMO) is an acute inflammatory disease that preferentially involves the optic nerves and spinal cord. Although many infectious agents, including mumps virus, are postulated to have a role in the pathogenesis of multiple sclerosis (MS), the relationship between NMO and infectious agents remains uncertain. To investigate the relationship between NMO and viruses that have special affinity for the central nervous system, we performed a nested polymerase chain reaction (PCR) to detect mumps virus or enterovirus RNA in cerebrospinal fluid samples from 13 patients with MS, 8 with NMO and 20 with other neurological diseases (ONDs). Nested PCR was positive for mumps virus in 2 (25%) of NMO patients, but in none of those with MS and ONDs. Moreover, nested PCR results became negative in the remission phase in the two PCR-positive NMO patients. Mumps virus may have some role in the pathogenesis of NMO.
视神经脊髓炎（NMO）是一种以视神经和脊髓为优先受累部位的急性炎症性疾病。虽然许多感染因子，包括腮腺炎病毒，被推测在多发性硬化症（MS）的发病机制中起作用，但 NMO 与感染因子之间的关系仍不确定。为了研究 NMO 与对中枢神经系统具有特殊亲和力的病毒之间的关系，我们对 13 例 MS 患者、8 例 NMO 患者和 20 例其他神经疾病（OND）患者的脑脊液样本进行了巢式聚合酶链反应（PCR）以检测腮腺炎病毒或肠道病毒 RNA。巢式 PCR 在 2 例（25%）NMO 患者中呈腮腺炎病毒阳性，但在 MS 和 OND 患者中均为阴性。此外，在 2 例 PCR 阳性的 NMO 患者的缓解期，巢式 PCR 结果转为阴性。腮腺炎病毒可能在 NMO 的发病机制中起一定作用。
