Turco Emanuela Claudia, Curti Erica, Maffini Valentina, Pisani Francesco, Granella Franco
Child Neuropsychiatric Unit, Maternal and Child Health Department, Parma University Hospital, Via Gramsci 14, 43126 Parma, Italy.
Unit of Neurosciences, Department of Medicine and Surgery, University of Parma, Italy.
Mult Scler Int. 2020 Apr 25;2020:6151258. doi: 10.1155/2020/6151258. eCollection 2020.
Neuromyelitis optica spectrum disorder is a severe autoimmune disease of the central nervous system characterized by recurrent inflammatory events primarily involving the optic nerves and spinal cord. Recently, a triggering role of infectious events in the development of NMOSD has been suggested. Varicella zoster virus is the most common viral infection involved, though the linkage with anti-aquaporin-4 antibodies is so far unknown. We report, to the best of our knowledge, the first pediatric case report about NMOSD relapse triggered by herpes zoster infection. The strict temporal relationship between VZV infection and NMO attacks seems to be more than simply due to chance; however, further reports are needed to be confirmed.
视神经脊髓炎谱系障碍是一种严重的中枢神经系统自身免疫性疾病，其特征是反复出现主要累及视神经和脊髓的炎症事件。最近，有研究表明感染事件在视神经脊髓炎谱系障碍的发病过程中起到触发作用。水痘带状疱疹病毒是最常见的相关病毒感染，不过其与抗水通道蛋白4抗体之间的联系目前尚不清楚。据我们所知，我们报告了首例由带状疱疹感染引发的视神经脊髓炎谱系障碍复发的儿科病例。水痘带状疱疹病毒感染与视神经脊髓炎发作之间严格的时间关系似乎并非仅仅是巧合；然而，还需要更多报告来证实这一点。
