丝状病毒的实验室检测与诊断。
Laboratory detection and diagnosis of filoviruses.
机构信息
Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
出版信息
Virol Sin. 2011 Apr;26(2):73-80. doi: 10.1007/s12250-011-3186-9. Epub 2011 Apr 7.
Abstract
Ebola virus (EBOV) and Marburg virus (MARV), belonging to the Filoviridae family, emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates. As high as 50-90% mortality, filoviruses can cause significant threats to public health. However, so far no specific and efficient vaccine has been available, nor have other treatment methods proved to be effective. It is of great importance to detect these pathogens specific, rapidly and sensitively in order to control future filovirus outbreaks. Here, recent progresses in the development of detection and diagnosis methods for EBOV and MARV are summarized.
摘要
埃博拉病毒（EBOV）和马尔堡病毒（MARV）属于丝状病毒科，四十多年前出现，可导致人类和其他灵长类动物发生严重的病毒性出血热。丝状病毒的致死率高达 50-90%，对公共卫生造成严重威胁。但迄今为止，尚无特效和有效的疫苗，其他治疗方法也未被证实有效。因此，开发针对这些病原体的特异性、快速和敏感的检测方法对于控制未来丝状病毒的爆发具有重要意义。本文总结了目前针对 EBOV 和 MARV 的检测和诊断方法的研究进展。
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