Crosspatch, 3 Bossington Oast, Adisham, Canterbury, Kent, UK.
Curr Top Med Chem. 2011;11(15):1925-43. doi: 10.2174/156802611796391302.
Thematic Analysis™ is a chemogenomic tool which has been developed and used to aid the process of GPCR drug discovery. This review covers the scientific rationale behind the development of this tool and provides examples of the successful application of the chemogenomic method in both hit finding and hit to lead stages of the drug discovery process.
主题分析™是一种化学生物基因组学工具，已被开发并用于辅助 GPCR 药物发现过程。本文综述了该工具开发的科学原理，并提供了该化学生物基因组学方法在药物发现过程中的发现阶段和先导化合物优化阶段成功应用的实例。
