Valavaara R, Tuominen J, Johansson R
Department of Radiotherapy, University of Turku, Finland.
Cancer. 1990 Dec 1;66(11):2264-9. doi: 10.1002/1097-0142(19901201)66:11<2264::aid-cncr2820661103>3.0.co;2-9.
The predictive value of estrogen receptor (ER) concentrations was evaluated in a group of 113 postmenopausal patients with estrogen-receptor-positive (ER greater than 7 fmol/mg protein) advanced breast cancer. In 103 patients, tumors were also sampled for progesterone receptor (PgR) determination. All patients were treated with toremifene, a novel antiestrogen, 60 mg daily. The median ER in 51 responders was 78 fmol/mg protein, and in 62 nonresponders, 51 fmol/mg protein; the median PgR levels were 40 and 37 fmol/mg protein, respectively. The response rate in patients with ER less than 50 fmol/mg protein was 38%, and 51% in the group with ER greater than 50 fmol/mg protein (not significant [NS]). The response rate in patients with PgR less than 10 fmol/mg protein was 42%, and in patients with greater than 10 fmol/mg protein, 44%. The duration of response in patients with ER greater than 50 fmol/mg protein was significantly longer than with lower ER levels (P = 0.002). PgR was not associated with the duration of response. In Cox's multiple regression analysis, ER was an independent prognostic factor (P = 0.005) for response duration. Thus, the ER concentration of tumor tissue predicts the duration of response but not the response rate to toremifene in patients with advanced breast cancer. The PgR status does not predict the response rate or the duration of response.
对113例雌激素受体阳性（ER大于7 fmol/mg蛋白）的绝经后晚期乳腺癌患者的雌激素受体（ER）浓度的预测价值进行了评估。在103例患者中，还采集肿瘤样本用于测定孕激素受体（PgR）。所有患者均接受托瑞米芬治疗，这是一种新型抗雌激素药物，每日60 mg。51例有反应患者的ER中位数为78 fmol/mg蛋白，62例无反应患者的ER中位数为51 fmol/mg蛋白；PgR水平中位数分别为40和37 fmol/mg蛋白。ER小于50 fmol/mg蛋白患者的反应率为38%，ER大于50 fmol/mg蛋白组为51%（无显著性差异[NS]）。PgR小于10 fmol/mg蛋白患者的反应率为42%，大于10 fmol/mg蛋白患者的反应率为44%。ER大于50 fmol/mg蛋白患者的反应持续时间显著长于ER水平较低者（P = 0.002）。PgR与反应持续时间无关。在Cox多元回归分析中，ER是反应持续时间的独立预后因素（P = 0.005）。因此，肿瘤组织的ER浓度可预测晚期乳腺癌患者对托瑞米芬的反应持续时间，但不能预测反应率。PgR状态不能预测反应率或反应持续时间。
