年龄相关性黄斑变性与另一条双螺旋。科根讲座。
Age-related macular degeneration and the other double helix. The Cogan Lecture.
机构信息
Department of Ophthalmology and Vision Sciences, University of Kentucky, 740 S. Limestone Street, Lexington, KY 40536-0284, USA.
出版信息
Invest Ophthalmol Vis Sci. 2011 Apr 6;52(5):2165-9. doi: 10.1167/iovs.11-7328. Print 2011 Apr.
Abstract
The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNAs (dsRNAs) in neovascular AMD and cytotoxic functions for endogenous dsRNAs in atrophic AMD. These findings provide new insights into the pathogenesis and therapy of both forms of AMD.
摘要
过去十年中，与年龄相关的黄斑变性（AMD）这种全球主要致盲原因的研究和治疗取得了巨大进展。与此同时，人们发现 RNA 在许多人类疾病中起着核心作用。我们已经发现，合成双链 RNA（dsRNA）在新生血管性 AMD 中具有抗血管生成功能，而内源性 dsRNA 在萎缩性 AMD 中具有细胞毒性功能。这些发现为这两种形式的 AMD 的发病机制和治疗提供了新的见解。
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