HIV 传播：转化研究弥合差距的时机已到。
HIV transmission: time for translational studies to bridge the gap.
机构信息
Center for HIV Prevention Research, Division of Digestive Diseases and UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Sci Transl Med. 2011 Apr 6;3(77):77ps11. doi: 10.1126/scitranslmed.3002329.
Abstract
More than 7000 new HIV infections are documented each day worldwide. In this Perspective, we dissect new results from a large clinical trial showing that genital and plasma HIV-1 RNA loads predict the risk of heterosexual transmission and that genital tract viral RNA load does so independently of plasma viral load. Furthermore, beyond its defined study end points, this well-conducted trial identified new research directions that should be pursued in smaller intensive basic and translational studies.
摘要
全球每天记录到超过 7000 例新的 HIV 感染。在本观点中，我们剖析了一项大型临床试验的新结果，该结果表明生殖器和血浆 HIV-1 RNA 载量可预测异性传播的风险，而生殖道病毒 RNA 载量可独立于血浆病毒载量预测风险。此外，除了明确的研究终点之外，这项精心设计的试验还确定了应在较小的密集基础和转化研究中进一步探索的新研究方向。
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2
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AIDS Res Hum Retroviruses. 2011 Oct;27(10):1067-72. doi: 10.1089/aid.2010.0362. Epub 2011 May 6.
3
Viral linkage in HIV-1 seroconverters and their partners in an HIV-1 prevention clinical trial.在一项 HIV-1 预防临床试验中，HIV-1 血清转换者及其性伴中的病毒关联。
PLoS One. 2011 Mar 2;6(3):e16986. doi: 10.1371/journal.pone.0016986.
4
Correlates of HIV-1 genital shedding in Tanzanian women.坦桑尼亚妇女体内 HIV-1 生殖器脱落物的相关因素。
PLoS One. 2011 Mar 1;6(3):e17480. doi: 10.1371/journal.pone.0017480.
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