Department of Plastic and Reconstructive Surgery, La Sapienza University of Rome, 00161 Rome, Italy.
In Vivo. 2011 Mar-Apr;25(2):291-5.
The objective of this study was to compare the efficacy and effectiveness between an analgesic combination of tramadol/paracetamol (37.5+325 mg), and paracetamol monotherapy (1000 mg) for acute postoperative pain after hand and foot surgery. The study design was a single blind randomized controlled trial. A total of 114 patients who underwent hand and foot surgery under brachial plexus block were randomized to receive either paracetamol monotherapy (group P, n=57) or tramadol/paracetamol (group TP, n=57) postoperatively. The number of patients who required an extra-dose of analgesic pain score, and adverse affects were compared between the two groups. Analgesic requirement was significantly lower in those in the TP group when compared with the P group. In the TP group, the pain score after surgery was significantly lower than in the P group. Adverse effects did not significantly differ between the two groups. There were no serious adverse events in either group. The association of tramadol and paracetamol appears to have more efficacy when compared with paracetamol monotherapy for acute postoperative pain after hand and foot surgery.
本研究旨在比较曲马多/对乙酰氨基酚（37.5+325mg）镇痛合剂与对乙酰氨基酚单药治疗（1000mg）在手和足手术后急性疼痛的疗效和有效性。研究设计为单盲随机对照试验。共纳入 114 例行臂丛阻滞下手和足手术的患者，随机分为接受对乙酰氨基酚单药治疗（P 组，n=57）或曲马多/对乙酰氨基酚（TP 组，n=57）治疗。比较两组患者的额外剂量需求、疼痛评分和不良反应。与 P 组相比，TP 组的镇痛需求明显降低。TP 组术后疼痛评分明显低于 P 组。两组不良反应无明显差异。两组均无严重不良事件。与对乙酰氨基酚单药治疗相比，曲马多和对乙酰氨基酚联合应用在手和足手术后急性疼痛的治疗中似乎更有效。
