Miller R J, Cuatrecasas P
Naturwissenschaften. 1978 Oct;65(10):507-14. doi: 10.1007/BF00439790.
Two penta-peptides with morphine-like properties have recently been found in the nervous system and gastrointestinal tract. These peptides known as enkephalins are unevenly distributed in the brain, the highest concentration being in the globus pallidus. The enkephalins are found to have analgesic properties and are also anti-tussive, anti-diarrheal and able to stimulate release of prolactin and growth hormone. Synthetic analogues of the enkephalins containing specific D-amino acid substitutions have been developed and show a wide spectrum of activities.
最近在神经系统和胃肠道中发现了两种具有吗啡样特性的五肽。这些被称为脑啡肽的肽在大脑中分布不均，最高浓度存在于苍白球。已发现脑啡肽具有镇痛特性，还具有镇咳、止泻作用，并能刺激催乳素和生长激素的释放。已经开发出含有特定D-氨基酸取代的脑啡肽合成类似物，它们表现出广泛的活性。
