Sáinz-Jaspeado Miguel, Martin-Liberal Juan, Lagares-Tena Laura, Mateo-Lozano Silvia, Garcia del Muro Xavier, Tirado Oscar M
Sarcoma Research Group, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain.
Oncotarget. 2011 Apr;2(4):305-12. doi: 10.18632/oncotarget.255.
Sarcomas represent a heterogeneous group of tumors with a complex and difficult reproducible classification. Their pathogenesis is poorly understood and there are few effective treatment options for advanced disease. Caveolin-1 is a multifunctional scaffolding protein with multiple binding partners that regulates multiple cancer-associated processes including cellular transformation, tumor growth, cell death and survival, multidrug resistance, angiogenesis, cell migration and metastasis. However, ambiguous roles have been ascribed to caveolin-1 in signal transduction and cancer, including sarcomas. In particular, evidence indicating that caveolin-1 function is cell context dependent has been repeatedly reported. Caveolin-1 appears to act as a tumor suppressor protein at early stages of cancer progression. In contrast, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. This review is focused on the role of caveolin-1 in several soft tissue and bone sarcomas and discusses the use of this protein as a potential diagnostic and prognostic marker and as a therapeutic target.
肉瘤是一组异质性肿瘤，其分类复杂且难以重复。它们的发病机制尚不清楚，对于晚期疾病几乎没有有效的治疗选择。小窝蛋白-1是一种多功能支架蛋白，有多个结合伴侣，可调节多种与癌症相关的过程，包括细胞转化、肿瘤生长、细胞死亡与存活、多药耐药、血管生成、细胞迁移和转移。然而，在信号转导和癌症（包括肉瘤）中，小窝蛋白-1的作用一直存在争议。特别是，有证据反复表明小窝蛋白-1的功能取决于细胞环境。在癌症进展的早期阶段，小窝蛋白-1似乎起着肿瘤抑制蛋白的作用。相反，越来越多的证据表明，小窝蛋白-1在几种多药耐药和转移性癌细胞系以及人类肿瘤标本中上调。本综述重点关注小窝蛋白-1在几种软组织和骨肉瘤中的作用，并讨论将该蛋白用作潜在诊断和预后标志物以及治疗靶点的情况。
