Barykova Yulia A, Logunov Denis Yu, Shmarov Maxim M, Vinarov Andrei Z, Fiev Dmitry N, Vinarova Natalia A, Rakovskaya Irina V, Baker Patricia Stanhope, Shyshynova Inna, Stephenson Andrew J, Klein Eric A, Naroditsky Boris S, Gintsburg Alexander L, Gudkov Andrei V
NF Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia.
Oncotarget. 2011 Apr;2(4):289-97. doi: 10.18632/oncotarget.256.
The origin of chronic inflammation preceding the development of prostate cancer (PCa) remains unknown. We investigated possible involvement of mycoplasma infection in PCa by screening prostate biopsies from two groups of Russian men undergoing PCa diagnosis. M. hominis was detected by standard PCR in 15% of the 125 patients in the first group and by quantitative real-time PCR in 37.4% of the 123 men in the second group. In both groups, stratification of patients according to diagnosis showed that M. hominis was present at three times higher frequency in patients with PCa than in those with benign prostatic hyperplasia. No M. hominis was detected in the prostates of 27 men without detectable prostate disease. In addition, PCa-positive men had higher titers of antibodies against M. hominis and average PSA levels were higher in M. hominis-positive men. These data, together with previous observations linking mycoplasma infection with cell transformation, genomic instability and resistance to apoptosis, suggest that M. hominis infection may be involved in PCa development and may, therefore, be a potential PCa marker and/or target for improved prevention and treatment of this disease.
前列腺癌（PCa）发生之前慢性炎症的起源尚不清楚。我们通过筛查两组接受PCa诊断的俄罗斯男性的前列腺活检样本，研究了支原体感染在PCa中的可能作用。在第一组的125名患者中，15%通过标准PCR检测到人型支原体；在第二组的123名男性中，37.4%通过定量实时PCR检测到该病原体。在两组中，根据诊断对患者进行分层分析显示，PCa患者中人型支原体的检出频率是良性前列腺增生患者的三倍。在27名未检测到前列腺疾病的男性前列腺中未检测到人型支原体。此外，PCa阳性男性针对人型支原体的抗体滴度更高，且人型支原体阳性男性的平均前列腺特异性抗原（PSA）水平更高。这些数据，连同之前将支原体感染与细胞转化、基因组不稳定和抗凋亡联系起来的观察结果，表明人型支原体感染可能与PCa的发生有关，因此可能是一种潜在的PCa标志物和/或改善该疾病预防与治疗的靶点。
