Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Menopause. 2011 Aug;18(8):869-72. doi: 10.1097/gme.0b013e31820cc60c.
The aim of this study was to evaluate the effect of estrogen on the vascular resistance of the central retinal artery in postmenopausal women, compared with placebo, using transorbital ultrasound with Doppler velocimetry.
We performed a prospective, randomized, triple-blinded placebo-controlled study. A total of 51 healthy postmenopausal women (follicle-stimulating hormone, >40 IU/L) with a mean (SD) age of 53.6 (4.8) years were studied. Participants were randomly allocated into two groups: placebo (n = 23) and estrogen (0.625 mg conjugated estrogens; n = 28). Transorbital Doppler velocimetric ultrasound was performed before and after treatment in sitting and supine positions.
The mean age was similar in both groups. The pulsatility index of the central retinal arteries had a significant decrease after the use of estrogen, when women were evaluated in the sitting position. Women who received placebo did not show any difference in pulsatility index of the central retinal arteries after treatment. When the same comparison was done with participants in the supine position, no difference was observed in either group.
Our study demonstrates that estrogen reduces the vascular resistance of the central retinal artery in postmenopausal women because of a vasodilatory effect.
本研究旨在通过经眶超声多普勒血流速度仪评估与安慰剂相比，雌激素对绝经后妇女视网膜中央动脉血管阻力的影响。
我们进行了一项前瞻性、随机、三盲、安慰剂对照研究。共纳入 51 名平均（标准差）年龄为 53.6（4.8）岁的健康绝经后妇女（卵泡刺激素，>40IU/L）。参与者被随机分配到两组：安慰剂（n=23）和雌激素（0.625mg 结合雌激素；n=28）组。治疗前后分别让患者取坐位和仰卧位，进行经眶多普勒超声检查。
两组的平均年龄相似。雌激素治疗后，当女性处于坐位时，视网膜中央动脉的搏动指数显著降低。接受安慰剂的女性在治疗后视网膜中央动脉的搏动指数没有差异。当对仰卧位的参与者进行同样的比较时，两组均未观察到差异。
我们的研究表明，雌激素通过舒张作用降低绝经后妇女视网膜中央动脉的血管阻力。
