Brandão Augusto H F, Serra Paula J, Zanolla Karla, Cabral Antônio C V, Geber Selmo
Department of Obstetrics and Gynecology - Universidade Federal de Minas Gerais - Belo Horizonte - MG - Brazil.
JBRA Assist Reprod. 2014 Dec 27;18(4):148-150. doi: 10.5935/1518-0557.20140022.
It is well defined that ovarian steroids play a role in the cardiovascular system, acting as vasoactive compounds. The aim of this study is to assess the endothelial function during the menstrual cycle using flow-mediated dilation of the brachial artery.
A total of 21 healthy premenopausal women, with regular menstrual cycles, were included in this observational, longitudinal, and prospective study. The endothelium function was assessed by ultrasound during four phases of the menstrual cycle: early follicular phase (EFP), late follicular phase (LFP), early luteal phase (ELP) and late luteal phase (LLP).
We observed a significant variation among the vasodilatation response during the menstrual cycle phases (P<0.001). The result was higher during LFP than during ELP (P<0.001) or LLP (P<0.001). Late luteal phase had higher response than observed during ELP (P=0.003) and EFP was higher than LLP (P=0.003). There were no significant differences between the results observed during EFP and LFP (P=1.0), or EFP and ELP (P=0.137).
Our results suggest that the ovarian steroids may play an important role in modulating endothelial function.
卵巢甾体激素作为血管活性化合物在心血管系统中发挥作用，这一点已得到充分证实。本研究的目的是利用肱动脉血流介导的扩张来评估月经周期中的内皮功能。
本观察性、纵向、前瞻性研究共纳入21名月经周期规律的健康绝经前女性。在月经周期的四个阶段，即卵泡早期（EFP）、卵泡晚期（LFP）、黄体早期（ELP）和黄体晚期（LLP），通过超声评估内皮功能。
我们观察到月经周期各阶段的血管舒张反应存在显著差异（P<0.001）。LFP阶段的结果高于ELP阶段（P<0.001）或LLP阶段（P<0.001）。黄体晚期的反应高于ELP阶段（P=0.003），EFP阶段高于LLP阶段（P=0.003）。EFP阶段和LFP阶段的结果之间（P=1.0），或EFP阶段和ELP阶段的结果之间（P=0.137）无显著差异。
我们的结果表明，卵巢甾体激素可能在调节内皮功能中起重要作用。
