School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China.
Molecules. 2011 Apr 6;16(4):2971-81. doi: 10.3390/molecules16042971.
Chiral C₂-symmetric diamines have emerged as versatile auxiliaries or ligands in numerous asymmetric transformations. Chiral 2,2'-bispyrrolidine-based salan ligands were prepared and applied to the asymmetric aryl transfer to aldehydes with arylboronic acids as the source of transferable aryl groups. The corresponding diarylmethanols were obtained in high yields with moderate to good enantioselectivitives of up to 83% ee.
手性 C₂ 对称二胺已成为许多不对称转化中通用的辅助剂或配体。合成了手性 2,2'-联吡咯啉基沙兰配体，并将其应用于不对称芳基转移反应，以芳基硼酸作为可转移芳基基团的来源。相应的二芳基甲醇以高收率和高达 83%ee 的中等至良好对映选择性获得。
