School of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
College of Chemistry and Environmental Engineering, Shaoguan University, Shaoguan 512005, China.
Molecules. 2022 Jun 17;27(12):3898. doi: 10.3390/molecules27123898.
Chiral alcohols are among the most widely applied in fine chemicals, pharmaceuticals and agrochemicals. Herein, the Ru-monophosphine catalyst formed in situ was found to promote an enantioselective addition of aliphatic aldehydes with arylboronic acids, delivering the chiral alcohols in excellent yields and enantioselectivities and exhibiting a broad scope of aliphatic aldehydes and arylboronic acids. The enantioselectivities are highly dependent on the monophosphorous ligands. The utility of this asymmetric synthetic method was showcased by a large-scale transformation.
手性醇是精细化学品、制药和农用化学品中应用最广泛的化合物之一。在此，我们发现原位形成的钌-单膦催化剂可以促进脂肪族醛与芳基硼酸的对映选择性加成，以优异的收率和对映选择性得到手性醇，并具有广泛的脂肪族醛和芳基硼酸的适用范围。对映选择性高度依赖于单磷配体。该不对称合成方法的实用性通过大规模转化得到了展示。
