Stefano Vita Di, Pitonzo Rosa, Schillaci Domenico
Department of Chemistry and Pharmaceutical Technology, Faculty of Pharmacy, University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Pharmacogn Mag. 2011 Jan;7(25):31-4. doi: 10.4103/0973-1296.75893.
Athamanta sicula L., a member of Apiaceae, is an annual perennial herb and it is known in Sicilian popular medicine with the name of "spaccapietre" (rock splitters), because fresh roots infusions are indicated as diuretic and used in the treatment of diseases of the urinary tract, and to dissolve kidney stones.
Acetone extracts of leaves, flowers, and stems of A. sicula L. were investigated in vitro for antibacterial and cytotoxic activities. Antimicrobial activity was carried out against bacterial and fungal strains and antiproliferative activity against a group of human cancer cell lines (K-562, NCI-H460, and MCF-7).
All acetone extracts, apiol and myristicin, resulted inactive as antimicrobial agents at the maximum tested concentration of 200 μg/mL, but they induced significant antiproliferative activity on the tested cancer cell lines.
Our study show that both apiol and myristicin could be tested as novel treatment in cancer chemotherapy.
西西里阿他曼塔草（Athamanta sicula L.）是伞形科的一种一年生多年生草本植物，在西西里传统医学中被称为“spaccapietre”（裂石草），因为其新鲜根的浸剂被用作利尿剂，用于治疗泌尿系统疾病和溶解肾结石。
对西西里阿他曼塔草的叶、花和茎的丙酮提取物进行了体外抗菌和细胞毒性活性研究。对细菌和真菌菌株进行了抗菌活性测试，并对一组人类癌细胞系（K-562、NCI-H460和MCF-7）进行了抗增殖活性测试。
在最高测试浓度200μg/mL时，所有丙酮提取物、芹菜脑和肉豆蔻醚作为抗菌剂均无活性，但它们对测试的癌细胞系具有显著的抗增殖活性。
我们的研究表明，芹菜脑和肉豆蔻醚都可以作为癌症化疗的新疗法进行测试。
