González J A, Estévez-Braun A, Estévez-Reyes R, Bazzocchi I L, Moujir L, Jimenez I A, Ravelo A G, González A G
Centro de Productos Naturales Orgánicos Antonio González, Instituto Universitario de Bio-Orgánica, Universidad de La Laguna, Tenerife, Canary Island, Spain.
Experientia. 1995 Jan 15;51(1):35-9.
Secondary metabolites from Bupleurum salicifolium were tested against viruses, Gram-positive and Gram-negative bacteria, the yeast Candida albicans, the nematodes Globodera pallida and G. rostochiensis, the insect Spodoptera littoralis and the crustacean Artemia salina. These compounds were also tested against tumoral and non-tumoral cell lines. The polyacetylene 8S-heptadeca-2(Z)-9(Z)-diene-4,6-diyne-1,8-diol exhibited toxicity for A. salina and specific antibiotic activity against Gram-positive bacteria. Nine of the lignans and one coumarin showed toxicity for A. salina, and the lignans bursehernin and matairesinol inhibited the hatching of the two nematode species. These are the first lignans that have been reported as affecting phytoparasitic nematodes, and the first natural products known to have an effect on the hatching of G. pallida. Lignans may play a role in the defence mechanisms of potato plants, as allelopathic substances acting against cyst-forming nematodes.
对柳叶柴胡的次生代谢产物进行了抗病毒、抗革兰氏阳性菌和革兰氏阴性菌、抗白色念珠菌酵母、抗马铃薯白线虫和罗斯托克马铃薯金线虫、抗斜纹夜蛾昆虫以及抗卤虫的测试。还对这些化合物进行了针对肿瘤细胞系和非肿瘤细胞系的测试。聚乙炔8S-十七碳-2(Z)-9(Z)-二烯-4,6-二炔-1,8-二醇对卤虫具有毒性，对革兰氏阳性菌具有特定的抗生素活性。九种木脂素和一种香豆素对卤虫具有毒性，木脂素紫丁香树脂醇和罗汉松脂素抑制了这两种线虫的孵化。这些是首次报道的对植物寄生线虫有影响的木脂素，也是已知的对马铃薯白线虫孵化有影响的首批天然产物。木脂素可能在马铃薯植株的防御机制中发挥作用，作为对抗形成孢囊线虫的化感物质。
