三种生态型多花百里香精油的化学成分及抗菌活性
Chemical composition and antimicrobial activities of the essential oils from three ecotypes of Zataria multiflora.
作者信息
Zomorodian K, Saharkhiz M J, Rahimi M J, Bandegi A, Shekarkhar G, Bandegani A, Pakshir K, Bazargani A
机构信息
Center of Basic Researches in Infectious Diseases, Shiraz, Iran.
出版信息
Pharmacogn Mag. 2011 Jan;7(25):53-9. doi: 10.4103/0973-1296.75902.
BACKGROUND
Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (ECTPs) of Z. multiflora essential oils (EOs) against most common causes of food-borne and nosocomial infections were evaluated.
MATERIALS AND METHODS
The antimicrobial activities of the EOs were examined by broth microdilution method as recommended by the Clinical and Laboratory Standards Institute (CLSI). The chemical compositions of the EOs from 3 ECTPs of Z. multiflora have been analyzed by gas chromatography-mass spectrometry.
RESULTS
Analysis of the EOs indicated that 3 chemotypes were present in Z. multiflora, including carvacrol, thymol-carvacrol, and linalool, whereas previous studies have only found carvacrol and thymol. Inhibition studies showed that the tested EOs entirely inhibited the growth of yeasts at concentrations of less than 1 μL/mL. Moreover, the oils exhibited significant bacteriostatic and bactericidal activities against Gram-positive and Gram-negative bacteria at concentrations ranging from 0.12 to 8 μL/mL.
CONCLUSION
These results suggest that the EOs from Z. multiflora should be investigated further for possible use in antimicrobial products and food preservatives.
背景
伊朗藏红花是一种传统且受欢迎的香料。对伊朗藏红花3种生态型（ECTP）精油（EO）针对食源性和医院感染最常见病因的作用进行了评估。
材料与方法
按照临床和实验室标准协会（CLSI）的建议，采用肉汤微量稀释法检测精油的抗菌活性。运用气相色谱 - 质谱联用仪分析了伊朗藏红花3种生态型精油的化学成分。
结果
精油分析表明，伊朗藏红花存在3种化学型，包括香芹酚型、百里香酚 - 香芹酚型和芳樟醇型，而先前的研究仅发现了香芹酚和百里香酚。抑制研究表明，受试精油在浓度低于1μL/mL时完全抑制酵母生长。此外，这些精油在浓度为0.12至8μL/mL时对革兰氏阳性菌和革兰氏阴性菌均表现出显著的抑菌和杀菌活性。
结论
这些结果表明，伊朗藏红花精油在抗菌产品和食品防腐剂中的潜在应用值得进一步研究。
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