Tsiligianni Ioanna, Kocks Janwillem, Tzanakis Nikolaos, Siafakas Nikolaos, van der Molen Thys
University Medical Center, University of Groningen, Groningen, The Netherlands.
Prim Care Respir J. 2011 Sep;20(3):257-68. doi: 10.4104/pcrj.2011.00029.
A major goal in the management of chronic obstructive pulmonary disease (COPD) is to ensure that the burden of the disease for patients with COPD is limited and that patients will have the best possible quality of life.
To explore all the possible factors that could influence disease-specific quality of life and health status in patients with COPD.
A systematic review of the literature and a meta-analysis were performed to explore the factors that could have a positive or negative effect on quality of life and/or health status in patients with COPD.
Quality of life and health status are determined by certain factors included gender, disease severity indices, lung function parameters, body mass index, smoking, symptoms, co-morbidity, depression, anxiety, and exacerbations. Factors such as dyspnoea, depression, anxiety and exercise tolerance were found to be more correlated with health status than the widely used spirometric values. Forced expiratory volume in one second had a weak to modest Pearson weighted correlation coefficient which ranged from -0.110 to -0.510 depending on the questionnaire used.
The broad range of determining factors suggests that, in order to reach the management goals, health status should be measured in addition to lung function in patients with COPD.
慢性阻塞性肺疾病（COPD）管理的一个主要目标是确保COPD患者的疾病负担得到限制，并且患者将拥有尽可能好的生活质量。
探讨所有可能影响COPD患者特定疾病生活质量和健康状况的因素。
进行了一项文献系统综述和荟萃分析，以探讨可能对COPD患者生活质量和/或健康状况产生正面或负面影响的因素。
生活质量和健康状况由某些因素决定，这些因素包括性别、疾病严重程度指数、肺功能参数、体重指数、吸烟、症状、合并症、抑郁、焦虑和病情加重。发现诸如呼吸困难、抑郁、焦虑和运动耐量等因素与健康状况的相关性比广泛使用的肺量计值更高。一秒用力呼气量的Pearson加权相关系数较弱至中等，根据所使用的问卷，其范围为-0.110至-0.510。
广泛的决定因素表明，为了实现管理目标，除了肺功能外，还应测量COPD患者的健康状况。
