Staten Island University Hospital, 475 Seaview Ave, Staten Island, NY 10305, USA.
Med Oncol. 2012 Jun;29(2):1109-13. doi: 10.1007/s12032-011-9886-z. Epub 2011 Apr 7.
Multisystemic Castleman disease (MCD) can be associated with HHV8 infection, which involves the mantle zone of follicles. This condition results in an increase number of HHV8-positive (HHV8+) plasmablasts that multiply and amalgamate to form plasmablastic B-cell lymphoma. All previously reported cases of HIV-positive patients with MCD were coinfected with HHV8. Twelve cases of HIV- MCD that are HHV8+ were encountered in the literature, three of them developed lymphoma, and none of those cases were reported to have Kaposi's sarcoma (KS). We report a unique case of HIV-negative elderly woman with preexisting KS that presented to the hospital with recurring nausea, vomiting, and fever, assessment revealed diffuse lymphadenopathy. Axillary lymph node biopsy showed HHV8+ MCD with foci of microlymphoma. Despite the treatment with high-dose steroids, she developed multisystem failure that lead to her death.
多系统 Castleman 病（MCD）可与 HHV8 感染相关，其涉及滤泡套区。这种情况会导致大量 HHV8 阳性（HHV8+）浆母细胞的增加，这些浆母细胞增殖并融合形成浆母细胞性 B 细胞淋巴瘤。所有先前报道的 HIV 阳性 MCD 患者均合并 HHV8 感染。文献中报道了 12 例 HIV-MCD 患者 HHV8 阳性，其中 3 例发展为淋巴瘤，且均未报告卡波西肉瘤（KS）。我们报告了一例独特的 HIV 阴性老年女性病例，该患者患有先前存在的 KS，因反复恶心、呕吐和发热就诊，评估发现弥漫性淋巴结病。腋窝淋巴结活检显示 HHV8+MCD 伴微淋巴瘤灶。尽管接受了大剂量类固醇治疗，但她仍出现多系统衰竭，最终导致死亡。
