Moulin G, Augey F
Service de Dermatologie, Hôpital de l'Antiquaille, Lyon.
Presse Med. 1990 Oct 27;19(35):1623-6.
Pyoderma gangrenosum is a very strange disease usually diagnosed on clinical grounds only and without any characteristic biological disturbance. It must be neither missed nor diagnosed too easily at the expense of vascular or infective ulcerations which are much more frequent. Its physiopathology remains shrouded in mystery since the abnormalities that have been found were extremely varied and sometimes conflicting, and were observed in short series. Thus, pyoderma gangrenosum appears as a syndrome which if often causeless or due to multiple diseases and might well be split into different entities in the forthcoming years. Despite its obscure pathogenesis, most patients can be cured by systemic corticosteroid therapy, sulfones or clofazimine. The main point of interest of that disease is that in almost 50 percent of the cases it is associated with a severe underlying pathology.
坏疽性脓皮病是一种非常奇特的疾病，通常仅基于临床症状进行诊断，且没有任何特征性的生物学紊乱。既不能漏诊，也不能轻易诊断，以免误诊为更常见的血管性或感染性溃疡。其病理生理学仍笼罩在谜团之中，因为所发现的异常情况极为多样，有时甚至相互矛盾，且观察的病例数量较少。因此，坏疽性脓皮病似乎是一种综合征，常常病因不明或由多种疾病引起，很可能在未来几年被分为不同的实体。尽管其发病机制不明，但大多数患者可通过全身使用皮质类固醇激素、砜类药物或氯法齐明治愈。该疾病的主要关注点在于，几乎50%的病例与严重的潜在病理状况相关。
