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[光学相干断层扫描在黄斑诊断中的应用——可能性与局限性]

[OCT in macular diagnostics - possibilities and limitations].

作者信息

Gamulescu M A, Helbig H

机构信息

Augenklinik, Universitätsklinikum Regensburg.

出版信息

Klin Monbl Augenheilkd. 2011 Jul;228(7):599-606. doi: 10.1055/s-0029-1245740. Epub 2011 Apr 6.

Abstract

During the last years, optical coherence tomography (OCT) has evolved to an important diagnostic tool in ophthalmology. In addition to ophthalmoscopy and the topographic visualisation of pathologies of the posterior part of the eye by fluorescein and indocyanine-green angiography, OCT adds complementary tomographic information on the retinal structures. First generation (time domain) OCT machines already generated pictures that resemble histological cross-sections of the retina. With the new OCTs of the spectral/frequency/Fourier domain generation, topographic and tomographic information can be presented side-by-side or in combination, thereby increasing the accuracy of the localisation of the visualised structures. Because of its non-invasive methodology without contact to the patient's eye and the faster acquisition times with increasing resolution, the OCT has become a valuable instrument in the modern anatomic and structural diagnostics of the macula. Functional statements are not yet possible in a comprehensive manner, but first steps have been made with the interpretation of structural information from high-resolution images. In this paper, the emerging possibilities from a widespread use of the OCT, as well as the limitations of this diagnostic technique, are discussed.

摘要

在过去几年中,光学相干断层扫描(OCT)已发展成为眼科重要的诊断工具。除了检眼镜检查以及通过荧光素和吲哚菁绿血管造影对眼后部病变进行地形图可视化外,OCT还能提供有关视网膜结构的补充断层扫描信息。第一代(时域)OCT机器已经能够生成类似于视网膜组织学横截面的图像。随着光谱/频率/傅里叶域新一代OCT的出现,地形图和断层扫描信息可以并排呈现或组合呈现,从而提高了可视化结构定位的准确性。由于其非侵入性方法,无需接触患者眼睛,且采集时间更快,分辨率不断提高,OCT已成为现代黄斑区解剖和结构诊断的重要工具。目前还无法全面进行功能评估,但在解读高分辨率图像的结构信息方面已经迈出了第一步。本文将讨论OCT广泛应用带来的新可能性以及这种诊断技术的局限性。

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