威尔布兰德氏无柄瓜中的新细胞毒素葫芦素
New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn.
机构信息
Department of Chemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
出版信息
Planta Med. 2011 Sep;77(14):1648-51. doi: 10.1055/s-0030-1270962. Epub 2011 Apr 6.
PMID:21472651
Abstract
Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (1- 2) and four known (3- 6) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity.
摘要
对Wilbrandia ebracteata Cogn.（葫芦科）的根进行化学研究，分离得到两种新的（1-2）和四种已知的（3-6）葫芦素。通过 NMR 和 MS 确定了它们的结构，并与相关化合物进行了比较。对分离得到的化合物进行了体外细胞毒性测试，结果显示对 RD、KB、HCT-8 和 A549 细胞系具有很强的活性。
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