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来自苦西瓜（Citrullus colocynthis (L.) Schrad.）叶片的葫芦素

Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad.

作者信息

Chawech Rachid, Jarraya Raoudha, Girardi Cynthia, Vansteelandt Marieke, Marti Guillaume, Nasri Imen, Racaud-Sultan Claire, Fabre Nicolas

机构信息

Université de Toulouse, UPS, Pharma-DEV, UMR 152, Université Toulouse 3, Faculté des Sciences Pharmaceutiques, F-31062 Toulouse cedex 09, France.

Institut de Recherche pour le Développement (IRD), UMR 152 Pharma-DEV, F-31062 Toulouse cedex 09, France.

出版信息

Molecules. 2015 Sep 30;20(10):18001-15. doi: 10.3390/molecules201018001.

DOI:10.3390/molecules201018001
PMID:26437392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6332406/
Abstract

Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines.

摘要

从苦西瓜叶的乙酸乙酯提取物中分离出两种新的四环葫芦烷型三萜糖苷以及四种已知的葫芦素。根据它们的光谱数据（主要是核磁共振和质谱）确定了它们的结构。对分离出的化合物针对两种人类结肠癌细胞系（HT29和Caco-2）和一种正常大鼠肠上皮细胞系（IEC6）的体外细胞毒性活性进行评估，结果显示其中一种分离出的化合物对结肠癌细胞系呈现出有趣的特异性细胞毒性活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5103/6332406/770c7d35d4e0/molecules-20-18001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5103/6332406/1e40647f65cd/molecules-20-18001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5103/6332406/ee8fbb5fdc72/molecules-20-18001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5103/6332406/770c7d35d4e0/molecules-20-18001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5103/6332406/1e40647f65cd/molecules-20-18001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5103/6332406/ee8fbb5fdc72/molecules-20-18001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5103/6332406/770c7d35d4e0/molecules-20-18001-g003.jpg

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