Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar-608 002, India.
J Biochem Mol Toxicol. 2011 Mar-Apr;25(2):68-76. doi: 10.1002/jbt.20360.
We evaluated the protective effects of gallic acid (3,4,5-trihydroxybenzoic acid) on hepatic lipid peroxidation products, antioxidants, glycoprotein components, and lipids in streptozotocin-induced type II diabetic rats. To induce type II diabetes, rats were injected with streptozotocin intraperitoneally at a single dose of 40 mg/kg. Gallic acid (10 and 20 mg/kg) treatment was given to diabetic rats orally using an intragastric tube daily for 21 days. Streptozotocin-induced diabetic rats showed a significant increase in the levels of blood glucose, hepatic lipid peroxidation products, glycoprotein components, lipids, and the activity of HMG-CoA reductase and a significant decrease in the levels of plasma insulin and liver glycogen. In addition to this, the activities/levels of hepatic antioxidants were decreased in diabetic rats. Gallic acid (10 and 20 mg/kg) treatment showed significant protective effects on all the biochemical parameters studied in diabetic rats. Thus, our study shows the antihyperglycemic, antilipid peroxidative, antioxidant, and antilipidemic effects of gallic acid in streptozotocin-induced type II diabetic rats. A diet containing gallic acid may be beneficial to type II diabetic patients.
我们评估了没食子酸（3,4,5-三羟基苯甲酸）对链脲佐菌素诱导的 II 型糖尿病大鼠肝脂质过氧化产物、抗氧化剂、糖蛋白成分和脂质的保护作用。为了诱导 II 型糖尿病，大鼠一次性腹腔内注射链脲佐菌素 40mg/kg。用胃管每天给糖尿病大鼠口服没食子酸（10 和 20mg/kg），连续 21 天。链脲佐菌素诱导的糖尿病大鼠血糖、肝脂质过氧化产物、糖蛋白成分、脂质、HMG-CoA 还原酶活性显著升高，血浆胰岛素和肝糖原水平显著降低。此外，糖尿病大鼠肝抗氧化剂的活性/水平降低。没食子酸（10 和 20mg/kg）治疗对糖尿病大鼠研究的所有生化参数均显示出显著的保护作用。因此，我们的研究表明没食子酸具有抗高血糖、抗脂质过氧化、抗氧化和抗脂作用在链脲佐菌素诱导的 II 型糖尿病大鼠中。含有没食子酸的饮食可能对 II 型糖尿病患者有益。
