Cheĭdo M A, Idova G V
Ross Fiziol Zh Im I M Sechenova. 2010 Dec;96(12):1234-40.
The present study indicates involvement of serotoninergic (5-HTergic) mechanisms in immunosuppression by DSLET (100 mkg/kg), a selective agonist of the delta2-opioid receptors, in CBA mice. 8-OH-DPAT (0.1 mg/kg), a selective agonist of the 5-HT(1A)-autoreceptors, WAY-100635 (1, 3 mg/kg) and ketanserin (1, 3 mg/kg), a selective antagonists of the postsynaptic 5-HT(1A)- and 5-HT(2A)-receptors, respectively, prevented immunosuppressive effect of DSLET. A possible differential role for 5-HT-receptors in delta-opioid immunosuppression is suggested.
本研究表明，δ2-阿片受体的选择性激动剂DSLET（100微克/千克）在CBA小鼠中诱导的免疫抑制涉及5-羟色胺能（5-HT能）机制。5-HT(1A)自身受体的选择性激动剂8-OH-DPAT（0.1毫克/千克）、突触后5-HT(1A)受体和5-HT(2A)受体的选择性拮抗剂WAY-100635（1、3毫克/千克）和酮色林（1、3毫克/千克）可预防DSLET的免疫抑制作用。这表明5-HT受体在δ-阿片类药物诱导的免疫抑制中可能具有不同的作用。
