Griffis Charles A
University of California, Los Angeles, Department of Anesthesiology, Los Angeles, California, USA.
AANA J. 2011 Feb;79(1):31-7.
Chronic pain is an extremely debilitating disease syndrome for which current treatment modalities are largely ineffective. This article presents the recently proposed contributions of neuroimmune activation to the maintenance of chronic pain. The theory of neuroimmune activation postulates a pathway that links peripheral neuronal injury/inflammation with the activation of central nervous system neuroglial cells, which contributes to sustained neuronal hyperexcitability. Literature generated by the emerging field of central nervous system glial cell research, including genetic therapies, was reviewed to provide empirical support for this pathway. The clinical implications of neuroimmune activation to improved treatment of chronic pain states are discussed.
慢性疼痛是一种极其使人衰弱的疾病综合征，目前的治疗方式对此大多无效。本文介绍了最近提出的神经免疫激活在慢性疼痛维持中的作用。神经免疫激活理论假定了一条将外周神经元损伤/炎症与中枢神经系统神经胶质细胞激活联系起来的途径，这导致神经元持续过度兴奋。对包括基因疗法在内的中枢神经系统胶质细胞研究新兴领域所产生的文献进行了综述，以支持这一途径。讨论了神经免疫激活对改善慢性疼痛状态治疗的临床意义。
