Peters K M, Leusch H G, Bruchhausen B, Schilgen M, Markos-Pusztai S
Orthopädische Klinik, Medizinischen Fakultät, RWTH Aachen.
Z Orthop Ihre Grenzgeb. 1990 Sep-Oct;128(5):453-6. doi: 10.1055/s-2008-1039595.
HIV-1 and HIV-2 antibodies, erythrocyte sedimentation rate, leucocytes and additionally serum neopterin levels were measured in 100 potential spongiosa donors. HIV antibodies were negative in all patients, whereas in 24% neopterin levels were elevated (greater than 10 nmol/l). Enhanced neopterin production is related to activity in cell-mediated immune response. In further investigations of these patients we found in 29% infections, 38% tumor diseases and 13% autoimmune diseases, all being exclusion criteria for spongiosa transplantation. In 3 patients increased neopterin values were the only pathological screening parameters. The measurement of serum neopterin levels showed to be a helpful parameter for the selection of spongiosa donors.
对100名潜在的海绵体供体检测了HIV-1和HIV-2抗体、红细胞沉降率、白细胞，另外还检测了血清新蝶呤水平。所有患者的HIV抗体均为阴性，而24%的患者新蝶呤水平升高（大于10 nmol/l）。新蝶呤产生增加与细胞介导的免疫反应活性有关。在对这些患者的进一步调查中，我们发现29%患有感染性疾病，38%患有肿瘤疾病，13%患有自身免疫性疾病，这些都是海绵体移植的排除标准。在3名患者中，新蝶呤值升高是唯一的病理筛查参数。血清新蝶呤水平的检测结果表明，它是选择海绵体供体的一个有用参数。
