Haas R, Gerstner L
Allerg Immunol (Leipz). 1985;31(3):179-82.
In 518 sera from blood donors below 30 years of age Neopterin was determined by radioimmunoassay. 21 of these patients (= 4.05%) showed elevated serum levels for Neopterin. By clinical investigation of these cases viral infections of the upper airways were found. Furthermore after elimination of elevated values significant differences in normal Neopterin serum levels could be demonstrated for female and male blood donors (p less than 0.01). Because elevated Neopterin serum levels indicate immune responses to several antigens, determination of Neopterin from serum may be useful for detection of infectious blood samples.
采用放射免疫分析法对518份30岁以下献血者的血清进行了新蝶呤检测。其中21例患者（占4.05%）血清新蝶呤水平升高。通过对这些病例的临床调查发现了上呼吸道病毒感染。此外，在排除升高值后，男女献血者正常血清新蝶呤水平存在显著差异（p<0.01）。由于血清新蝶呤水平升高表明对多种抗原产生免疫反应，因此检测血清新蝶呤可能有助于发现感染性血液样本。
