Mumtaz Moiz M, Hansen Hugh, Pohl Hana R
Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta GA 30333, USA.
Met Ions Life Sci. 2011;8:61-80.
For communities generally and for persons living in the vicinity of waste sites specifically, potential exposures to chemical mixtures are genuine concerns. Such concerns often arise from perceptions of a site's higher than anticipated toxicity due to synergistic interactions among chemicals. This chapter outlines some historical approaches to mixtures risk assessment. It also outlines ATSDR's current approach to toxicity risk assessment. The ATSDR's joint toxicity assessment guidance for chemical mixtures addresses interactions among components of chemical mixtures. The guidance recommends a series of steps that include simple calculations for a systematic analysis of data leading to conclusions regarding any hazards chemical mixtures might pose. These conclusions can, in turn, lead to recommendations such as targeted research to fill data gaps, development of new methods using current science, and health education to raise awareness of residents and health care providers. The chapter also provides examples of future trends in chemical mixtures assessment.
对于一般社区，特别是居住在废物处理场附近的居民而言，潜在接触化学混合物确实令人担忧。这类担忧通常源于人们认为由于化学物质之间的协同相互作用，场地的毒性高于预期。本章概述了一些混合物风险评估的历史方法。它还概述了美国毒物与疾病登记署（ATSDR）目前的毒性风险评估方法。ATSDR关于化学混合物的联合毒性评估指南涉及化学混合物各成分之间的相互作用。该指南推荐了一系列步骤，包括进行简单计算，以便对数据进行系统分析，从而得出关于化学混合物可能造成的任何危害的结论。这些结论进而可以引出一些建议，比如开展有针对性的研究以填补数据空白、利用现有科学开发新方法，以及开展健康教育以提高居民和医疗服务提供者的认识。本章还提供了化学混合物评估未来趋势的示例。
