Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113-8656, Japan.
Org Lett. 2011 May 6;13(9):2460-3. doi: 10.1021/ol200703g. Epub 2011 Apr 7.
The enantioselective propargylic amination of propargylic pentafluorobenzoates bearing an alkyl group at the propargylic position with amines in the presence of catalytic amounts of a copper complex and an optically active diphosphine such as BINAP has been found to give the corresponding propargylic amines in good yields with high enantioselectivity.
手性膦配体 BINAP 催化下，带有烷基取代基的炔丙基五氟苯甲酸酯与胺的对映选择性炔丙基胺化反应，在催化量的铜配合物存在下，可以以高产率和高对映选择性得到相应的炔丙基胺。
