Institute of Engineering Innovation, School of Engineering, The University of Tokyo , Yayoi, Bunkyo-ku, Tokyo, 113-8656, Japan.
J Am Chem Soc. 2015 Feb 25;137(7):2472-5. doi: 10.1021/jacs.5b00004. Epub 2015 Feb 16.
Enantioselective propargylic etherification of propargylic esters with not only aliphatic alcohols but also phenols in the presence of a catalytic amount of copper-Pybox complex gives the corresponding propargylic ethers in good to high yields with a high to excellent enantioselectivity (up to 99% ee). The result described here provides the first successful example of enantioselective propargylic etherification.
在催化量的铜-Pybox 配合物存在下，不仅可以使丙炔酯与脂肪醇，还可以与酚进行对映选择性丙炔醚化反应，以高至优异的对映选择性（高达 99%ee）得到相应的丙炔醚，产率良好至很高。这里描述的结果提供了对映选择性丙炔醚化反应的第一个成功实例。
