School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia.
Biomark Med. 2011 Apr;5(2):149-54. doi: 10.2217/bmm.11.16.
Immune restoration disease associated with Mycobacterium tuberculosis is a complication of antiretroviral therapy seen in a subset of HIV-1 patients soon after they commence antiretroviral therapy. It is characterized by a 'paradoxical' worsening of treated tuberculosis or an 'unmasking' of subclinical tuberculosis. As antiretroviral therapy becomes increasingly available in countries with a high prevalence of tuberculosis, this form of immune restoration disease will become more common. Here we summarize biomarkers that may illuminate immunopathogenesis and assist in diagnosis.
与结核分枝杆菌相关的免疫重建疾病是抗逆转录病毒治疗的一种并发症，在开始抗逆转录病毒治疗后不久，HIV-1 患者的一部分会出现这种并发症。其特征是治疗的肺结核“反常”恶化或亚临床结核病“显现”。随着在结核病高发国家中抗逆转录病毒疗法的日益普及，这种形式的免疫重建疾病将变得更加常见。在这里，我们总结了一些可能阐明免疫发病机制并有助于诊断的生物标志物。
