Paediatric HIV Diagnostic Syndicate, University of the Witwatersrand, Johannesburg, South Africa.
Pediatr Infect Dis J. 2013 Feb;32(2):157-62. doi: 10.1097/INF.0b013e31827031aa.
Immune reconstitution inflammatory syndrome occurs in a subset of HIV-infected individuals as the immune system recovers secondary to antiretroviral therapy. An exaggerated and uncontrolled inflammatory response to antigens of viable or nonviable organisms is characteristic, with clinical deterioration despite improvement in laboratory indicators. We describe a fatal case of Mycobacterium tuberculosis meningitis immune reconstitution inflammatory syndrome in an HIV-infected child and review the literature.
免疫重建炎症综合征发生于艾滋病病毒感染者中的一部分人群，当免疫系统因抗逆转录病毒治疗而恢复时出现。这种综合征的特征是针对活的或死的病原体抗原发生过度和失控的炎症反应，尽管实验室指标改善，但临床情况仍恶化。我们描述了一例艾滋病病毒感染儿童患结核分枝杆菌脑膜炎免疫重建炎症综合征的致死病例，并复习了文献。
