Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430-9097, USA.
Pharmacol Res. 2011 Aug;64(2):155-61. doi: 10.1016/j.phrs.2011.03.012. Epub 2011 Apr 5.
Osteoporosis is a major health problem in the elderly. Epidemiological evidence has shown an association between tea consumption and the prevention of bone loss in the elderly population. Ingestion of green tea and green tea bioactive compounds may be beneficial in mitigating bone loss of this population and decreasing their risk of osteoporotic fractures. This review describes the effect of green tea with its bioactive components on bone health with an emphasis on the following: (i) the etiology of osteoporosis, (ii) evidence of osteo-protective impacts of green tea on bone mass and microarchitecture in various bone loss models in which induced by aging, sex hormone deficiency, and chronic inflammation, (iii) discussion of impacts of green tea on bone mass in two obesity models, (iv) observation of short-term green tea supplementation given to postmenopausal women with low bone mass, (v) possible mechanisms for the osteo-protective effects of green tea bioactive compounds, and (vi) a summary and future research direction of green tea and bone health.
骨质疏松症是老年人的一个主要健康问题。流行病学证据表明，饮茶与老年人骨量流失的预防之间存在关联。摄入绿茶和绿茶生物活性化合物可能有助于减轻该人群的骨质流失，降低其骨质疏松性骨折的风险。本文综述了绿茶及其生物活性成分对骨骼健康的影响，重点介绍了以下几个方面：（i）骨质疏松症的病因；（ii）绿茶对衰老、性激素缺乏和慢性炎症等各种骨丢失模型中骨量和微结构的骨保护作用的证据；（iii）讨论绿茶对两种肥胖模型中骨量的影响；（iv）观察短期给予低骨量绝经后妇女绿茶补充剂的情况；（v）绿茶生物活性化合物的骨保护作用的可能机制；以及（vi）绿茶与骨骼健康的总结和未来研究方向。
