Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Mol Cell. 2011 Apr 8;42(1):4-5. doi: 10.1016/j.molcel.2011.03.008.
An intimate relationship exists between the transcriptional coregulator Daxx, SUMO, and PML nuclear bodies. In this issue, Chang et al. (2011) provide structural insights into how phosphorylation of Daxx increases its affinity toward SUMOs and functional insights into how enhanced SUMO binding affects Daxx-PML interactions, PML nuclear body localization, and Daxx-mediated repression of genes encoding for antiapoptotic factors.
转录共激活因子 Daxx、SUMO 和 PML 核小体之间存在密切关系。在本期杂志中，Chang 等人（2011）提供了结构方面的深入了解，阐明了 Daxx 的磷酸化如何增加其与 SUMO 的亲和力，以及功能方面的深入了解，即增强的 SUMO 结合如何影响 Daxx-PML 相互作用、PML 核小体定位以及 Daxx 介导的抗凋亡因子基因的抑制。
