马特斯痴呆评定量表检测帕金森病和 REM 睡眠行为障碍患者轻度认知障碍的有效性。
Validity of the Mattis Dementia Rating Scale to detect mild cognitive impairment in Parkinson's disease and REM sleep behavior disorder.
机构信息
Département de Psychologie, Université de Montréal, Montréal, Québec, Canada.
出版信息
Dement Geriatr Cogn Disord. 2011;31(3):210-7. doi: 10.1159/000326212. Epub 2011 Apr 7.
BACKGROUND/AIMS: Mild cognitive impairment (MCI) is frequent in Parkinson's disease (PD) and idiopathic REM sleep behavior disorder (iRBD). However, only a few studies have evaluated the validity of brief cognitive measures to detect MCI in PD or iRBD using standard diagnostic criteria for MCI. Our aim was to evaluate the validity of the Mini-Mental State Examination (MMSE) and the Mattis Dementia Rating Scale (DRS-2) to detect MCI in PD and iRBD.
METHODS
Forty PD patients and 34 iRBD patients were studied. Receiver operating characteristic curves were created for both tests to assess their effectiveness in identifying MCI in PD and iRBD.
RESULTS
In PD, a normality cutoff of 138 on the DRS-2 yielded the best balance between sensitivity (72%) and specificity (86%) with a correct classification of 80%. In iRBD, the optimal normality cutoff was 141 on the DRS-2, with a sensitivity of 90%, a specificity of 71% and a correct classification of 82%. No cutoff for the MMSE was found to have acceptable sensitivity or specificity.
CONCLUSION
The DRS-2 has satisfactory validity to detect MCI in PD or iRBD. The MMSE proved to be invalid as a screening test for MCI in both populations.
背景/目的：轻度认知障碍（MCI）在帕金森病（PD）和特发性 REM 睡眠行为障碍（iRBD）中很常见。然而，只有少数研究评估了使用 MCI 的标准诊断标准来检测 PD 或 iRBD 中简短认知措施的有效性。我们的目的是评估简易精神状态检查（MMSE）和 Mattis 痴呆评定量表（DRS-2）在 PD 和 iRBD 中检测 MCI 的有效性。
方法
研究了 40 名 PD 患者和 34 名 iRBD 患者。为这两项测试绘制了受试者工作特征曲线，以评估它们在识别 PD 和 iRBD 中的 MCI 方面的有效性。
结果
在 PD 中，DRS-2 的正常截断值为 138 时，在敏感性（72%）和特异性（86%）之间取得了最佳平衡，正确分类率为 80%。在 iRBD 中，DRS-2 的最佳正常截断值为 141，敏感性为 90%，特异性为 71%，正确分类率为 82%。没有发现 MMSE 的截断值具有可接受的敏感性或特异性。
结论
DRS-2 具有检测 PD 或 iRBD 中 MCI 的良好有效性。MMSE 被证明在这两种人群中作为 MCI 的筛查测试均无效。
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