Peláez Suárez Alejandro Armando, Berrillo Batista Sheila, Pedroso Ibáñez Ivonne, Casabona Fernández Enrique, Fuentes Campos Marinet, Chacón Lilia Morales
Movement Disorders and Neurodegeneration Clinic, International Center for Neurological Restoration, Playa, Havana 11300, Cuba.
Department of Clinical Neurophysiology, International Center for Neurological Restoration, Playa, Havana 11300, Cuba.
Behav Sci (Basel). 2021 Mar 23;11(3):40. doi: 10.3390/bs11030040.
To evaluate EEG-derived functional connectivity (FC) patterns associated with mild cognitive impairment (MCI) in Parkinson's disease (PD).
A sample of 15 patients without cognitive impairment (PD-WCI), 15 with MCI (PD-MCI), and 26 healthy subjects were studied. The EEG was performed in the waking functional state with eyes closed, for the functional analysis it was used the synchronization likelihood (SL) and graph theory (GT).
PD-MCI patients showed decreased FC in frequencies alpha, in posterior regions, and delta with a generalized distribution. Patients, compared to the healthy people, presented a decrease in segregation (lower clustering coefficient in alpha = 0.003 in PD-MCI patients) and increased integration (shorter mean path length in delta = 0.004) and theta = 0.002) in PD-MCI patients). There were no significant differences in the network topology between the parkinsonian groups. In PD-MCI patients, executive dysfunction correlated positively with global connectivity in beta (r = 0.47) and negatively with the mean path length at beta (r = -0.45); alterations in working memory were negatively correlated with the mean path length at beta r = -0.45.
PD patients present alterations in the FC in all frequencies, those with MCI show less connectivity in the alpha and delta frequencies. The neural networks of the patients show a random topology, with a similar organization between patients with and without MCI. In PD-MCI patients, alterations in executive function and working memory are related to beta integration.
评估帕金森病（PD）中与轻度认知障碍（MCI）相关的脑电图衍生功能连接（FC）模式。
研究了15名无认知障碍的患者（PD-WCI）、15名患有MCI的患者（PD-MCI）和26名健康受试者。在闭眼清醒功能状态下进行脑电图检查，功能分析使用同步似然性（SL）和图论（GT）。
PD-MCI患者在α频率的后部区域以及δ频率的广泛分布中显示FC降低。与健康人相比，患者在PD-MCI患者中表现出隔离减少（α聚类系数较低 = 0.003）和整合增加（δ平均路径长度较短 = 0.004）以及θ = 0.002）。帕金森病组之间的网络拓扑没有显著差异。在PD-MCI患者中，执行功能障碍与β频段的全局连接呈正相关（r = 0.47），与β频段的平均路径长度呈负相关（r = -0.45）；工作记忆的改变与β频段的平均路径长度呈负相关（r = -0.45）。
PD患者在所有频率的FC中均出现改变，患有MCI的患者在α和δ频率中的连接性较低。患者的神经网络显示出随机拓扑结构，MCI患者和非MCI患者之间的组织相似。在PD-MCI患者中，执行功能和工作记忆的改变与β整合有关。
