那法瑞林和达那唑对子宫内膜异位症患者椎骨小梁骨量的影响。

The effects of nafarelin and danazol on vertebral trabecular bone mass in patients with endometriosis.

作者信息

Whitehouse R W, Adams J E, Bancroft K, Vaughan-Williams C A, Elstein M

机构信息

Department of Diagnostic Radiology, University of Manchester, UK.

出版信息

Clin Endocrinol (Oxf). 1990 Sep;33(3):365-73. doi: 10.1111/j.1365-2265.1990.tb00501.x.

DOI:10.1111/j.1365-2265.1990.tb00501.x

PMID:2147597

Abstract

Single and dual-energy quantitative computed tomography (QCT) were used to measure spinal trabecular bone mineral content in 24 women treated with either nafarelin (15 patients) or danazol (nine patients) for endometriosis. Significant loss of bone mineral (-9.6 g/l; -5.9% P less than 0.001) was demonstrated after 6 months' treatment with nafarelin. This loss was reversible with no significant difference in the bone mineral measurement made before treatment and that made at 6 months after treatment was stopped (difference -1.95 g/l, NS). A small but statistically significant (+2.2 g/l, P less than 0.05) increase in bone mineral was measured in the group of patients treated with danazol for 6 months. The dual-energy QCT gave similar results, indicating little change in trabecular fat content. A significant correlation was demonstrated between mean serum oestradiol levels during treatment with nafarelin and the change in bone mineral (r = 0.655, P less than 0.005).

摘要

采用单能和双能定量计算机断层扫描（QCT）测量了24例因子宫内膜异位症接受那法瑞林治疗（15例患者）或达那唑治疗（9例患者）的女性的脊柱小梁骨矿物质含量。那法瑞林治疗6个月后，骨矿物质出现显著丢失（-9.6 g/l；-5.9%，P<0.001）。这种丢失是可逆的，治疗前与治疗停止6个月后的骨矿物质测量值无显著差异（差异为-1.95 g/l，无统计学意义）。接受达那唑治疗6个月的患者组骨矿物质有小幅但具有统计学意义的增加（+2.2 g/l，P<0.05）。双能QCT给出了相似结果，表明小梁脂肪含量变化不大。那法瑞林治疗期间的平均血清雌二醇水平与骨矿物质变化之间存在显著相关性（r = 0.655，P<0.005）。