Nielsen O H, Hvid-Jacobsen K, Lund P, Langholz E
Department of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark.
Digestion. 1990;46(2):89-96. doi: 10.1159/000200337.
Thirty-seven consecutive patients referred to a regional gastroenterology outpatient clinic with complaints of persistent nausea had a double isotopic scintigraphic evaluation of solid and liquid gastric emptying. Gastric emptying of both forms followed an exponential model. Marked day to day variation of gastric emptying was noted with a coefficient of variation of approximately 0.20 for both phases. Only 9 of 37 patients had delayed gastric emptying rate of the solid component (greater than 180 min) and no correlation between gastric stasis syndrome and nausea was established. Among these patients the median time for the stomach to empty 50% of the solid component was 261 min and 50% of the liquid component was 66 min. Treatment of these 9 patients shown to have gastric stasis syndrome and further 3 patients with diabetic gastroparesis with ondansetron, a highly selective antagonist of 5-hydroxytryptamine-3-receptors, resulted in a gastric emptying rate which was not statistically faster than after placebo (p = 0.11).
37名因持续性恶心而被转诊至某地区胃肠病门诊的连续患者接受了固体和液体胃排空的双同位素闪烁扫描评估。两种形式的胃排空均遵循指数模型。胃排空存在明显的每日变化，两个阶段的变异系数约为0.20。37名患者中只有9名固体成分胃排空延迟（超过180分钟），且未确立胃潴留综合征与恶心之间的相关性。在这些患者中，胃排空50%固体成分的中位时间为261分钟，排空50%液体成分的中位时间为66分钟。对这9名被证明患有胃潴留综合征的患者以及另外3名糖尿病性胃轻瘫患者使用5-羟色胺-3-受体的高度选择性拮抗剂昂丹司琼进行治疗，结果胃排空率在统计学上并不比使用安慰剂后更快（p = 0.11）。
