Wymenga A N, de Vries E G, Leijsma M K, Kema I P, Kleibeuker J H
Division of Medical Oncology, University Hospital, Groningen, The Netherlands.
Eur J Cancer. 1998 Jul;34(8):1293-4. doi: 10.1016/s0959-8049(98)00009-4.
The effect of short-term treatment with the highly selective serotonin receptor antagonist ondansetron on symptoms and gastric emptying in 11 carcinoid patients was studied. Diarrhoea improved in 6 of 6 patients, nausea in 3 of 4 patients. Flushing was not affected. The rate of gastric emptying increased during ondansetron treatment (P = 0.08). No changes in serotonin in platelets and urinary excretion of 5-hydroxyindoleacetic acid were found. It is concluded that ondansetron can improve gastrointestinal symptoms in carcinoid patients and possibly slows gastric emptying.
研究了高选择性5-羟色胺受体拮抗剂恩丹西酮短期治疗对11例类癌患者症状及胃排空的影响。6例腹泻患者中有6例症状改善，4例恶心患者中有3例症状改善。面部潮红未受影响。恩丹西酮治疗期间胃排空率增加（P = 0.08）。未发现血小板中5-羟色胺及尿中5-羟吲哚乙酸排泄量有变化。结论是恩丹西酮可改善类癌患者的胃肠道症状，并可能减慢胃排空。
