γ 射线或质子辐射暴露后小鼠白细胞计数分析。
Analysis of white blood cell counts in mice after gamma- or proton-radiation exposure.
机构信息
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
出版信息
Radiat Res. 2011 Aug;176(2):170-6. doi: 10.1667/RR2413.1. Epub 2011 Apr 8.
Abstract
In the coming decades human space exploration is expected to move beyond low-Earth orbit. This transition involves increasing mission time and therefore an increased risk of radiation exposure from solar particle event (SPE) radiation. Acute radiation effects after exposure to SPE radiation are of prime importance due to potential mission-threatening consequences. The major objective of this study was to characterize the dose-response relationship for proton and γ radiation delivered at doses up to 2 Gy at high (0.5 Gy/min) and low (0.5 Gy/h) dose rates using white blood cell (WBC) counts as a biological end point. The results demonstrate a dose-dependent decrease in WBC counts in mice exposed to high- and low-dose-rate proton and γ radiation, suggesting that astronauts exposed to SPE-like radiation may experience a significant decrease in circulating leukocytes.
摘要
在未来几十年，人类太空探索预计将超越近地轨道。这种转变涉及到增加任务时间，因此，来自太阳粒子事件（SPE）辐射的辐射暴露风险增加。由于潜在的危及任务的后果，暴露于 SPE 辐射后的急性辐射效应至关重要。本研究的主要目的是利用白细胞（WBC）计数作为生物终点，表征在高（0.5Gy/min）和低（0.5Gy/h）剂量率下，最高达 2Gy 剂量的质子和γ射线的剂量反应关系。结果表明，接受高剂量率和低剂量率质子和γ射线照射的小鼠的 WBC 计数呈剂量依赖性下降，这表明暴露于 SPE 样辐射的宇航员可能会经历循环白细胞的显著减少。
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