Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Retina. 2011 Jul-Aug;31(7):1387-91. doi: 10.1097/IAE.0b013e3182069a8f.
To describe the clinical course of patients with punctate inner choroidopathy seen at the University of Illinois, with emphasis on development of choroidal neovascularization (CNV).
Patients with a diagnosis of punctate inner choroidopathy were identified retrospectively. The diagnosis was made clinically based on findings of multiple, small "punched-out" lesions in the posterior pole without intraocular inflammation. Medical records were evaluated for evidence of CNV.
Twelve patients with a diagnosis of punctate inner choroidopathy were identified. Average age at presentation was 32 years (range, 24-52 years). Eleven were women, and 11 were white. Eleven patients had available refractive data: 10 were myopic. Eight had CNV at initial presentation, and 1 later developed CNV. Eight had follow-up averaging 4 years (range, 1.4-9.6 years). Of these, five had CNV at initial presentation, and five developed new CNV. Four had multiple CNV membranes. All 6 patients with follow-up of ≥ 3 years had visual acuity at 3 years postpresentation of >20/40 in at least 1 eye. Four had visual acuity >20/40 bilaterally.
Of punctate inner choroidopathy patients in this series, 75% had CNV, and more than 30% developed multiple neovascular membranes. With treatment, all patients with follow-up of ≥ 3 years had >20/40 vision in at least 1 eye.
描述在伊利诺伊大学就诊的点状内层脉络膜病变患者的临床过程，重点是脉络膜新生血管（CNV）的发生。
回顾性确定点状内层脉络膜病变患者。根据后极部多个小“凿孔样”病变而无眼内炎症的发现，临床诊断为点状内层脉络膜病变。评估病历以确定是否存在 CNV。
确定了 12 例点状内层脉络膜病变患者。发病时的平均年龄为 32 岁（范围，24-52 岁）。11 例为女性，11 例为白人。11 例患者有可获得的屈光数据：10 例为近视。初次就诊时 8 例有 CNV，1 例后来发生 CNV。8 例有平均 4 年（范围，1.4-9.6 年）的随访。其中，5 例初次就诊时有 CNV，5 例出现新的 CNV。4 例有多个 CNV 膜。6 例随访时间≥3 年的患者中，至少有 1 只眼在 3 年后的视力≥20/40。4 例双侧视力≥20/40。
在本系列点状内层脉络膜病变患者中，75%有 CNV，超过 30%出现多个新生血管膜。经治疗，所有随访时间≥3 年的患者中至少有 1 只眼的视力≥20/40。
