Agarwal Aniruddha, Handa Sabia, Marchese Alessandro, Parrulli Salvatore, Invernizzi Alessandro, Erckens Roel J, Berendschot Tos T J M, Webers C A B, Bansal Reema, Gupta Vishali
Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Cleveland Clinic, Eye Institute, Abu Dhabi, United Arab Emirates.
Front Med (Lausanne). 2021 Dec 22;8:758370. doi: 10.3389/fmed.2021.758370. eCollection 2021.
To analyze findings on optical coherence tomography (OCT) suggestive of choroidal neovascularization (CNV) in lesions of punctate inner choroidopathy (PIC). In this multi-center retrospective study, clinical data of patients with PIC were retrospectively analyzed. Quantitative data (height, width, and volume of PIC lesions), and qualitative data (disruption of ellipsoid zone (EZ)/Bruch's membrane (BM), outer retinal fuzziness, and choroidal back-shadowing) were compared between CNV+ and CNV- groups using Mann-Whitney -test and Fischer's exact test. In total, 35 eyes (29 patients; 21 women; mean age: 33.3 ± 6.5 years) were selected for analysis. Of the 35 PIC lesions studied, 17 had underlying CNV. Lesions with CNV+ had larger height, width, and volume ( < 0.001) and several distinctive features, such as disruption of EZ and BM, outer retinal fuzziness, and hypo-reflective back-shadowing ( < 0.001) compared with CNV-lesions. Quantitative and qualitative OCT analysis can aid in the prediction of an underlying CNV in the eyes with PIC.
分析点状内层脉络膜病变(PIC)病灶中光学相干断层扫描(OCT)提示脉络膜新生血管(CNV)的结果。在这项多中心回顾性研究中,对PIC患者的临床资料进行回顾性分析。使用Mann-Whitney检验和Fischer精确检验比较CNV阳性组和CNV阴性组的定量数据(PIC病灶的高度、宽度和体积)以及定性数据(椭圆体带(EZ)/布鲁赫膜(BM)破坏、外层视网膜模糊和脉络膜后阴影)。总共选择了35只眼(29例患者;21名女性;平均年龄:33.3±6.5岁)进行分析。在研究的35个PIC病灶中,17个存在潜在的CNV。与CNV阴性病灶相比,CNV阳性病灶具有更大的高度、宽度和体积(<0.001)以及一些独特特征,如EZ和BM破坏、外层视网膜模糊和低反射性后阴影(<0.001)。定量和定性OCT分析有助于预测PIC患者眼中潜在的CNV。