Prince Henry's Institute, Clayton, Vic. 3168, Australia.
Asian J Androl. 2011 May;13(3):424-31. doi: 10.1038/aja.2011.13. Epub 2011 Apr 11.
The decline in serum testosterone in ageing men may be mediated in part by obesity; however, it is uncertain which measure of adiposity is most closely associated with testosterone levels. We have examined the relationships of age, adiposity and testosterone levels in ageing men with symptoms consistent with hypoandrogenism but who were otherwise in good health. We conducted a cross-sectional study of non-smoking men aged ≥ 54 years recruited from the community and who were free of cancer or serious medical illness. Height (Ht), weight and waist circumference (WC) were measured, and body mass index (BMI) and waist-to-height (WHt) ratio were calculated. Two morning blood samples were collected for measurement of total testosterone (TT), sex hormone binding globulin (SHBG) and luteinizing hormone (LH). Free testosterone (cFT) was calculated. Multivariate linear regression analysis was performed to assess their relationship with measures of adiposity. Two hundred and seven men aged 54-86 years were studied. On univariate analysis WHt ratio was more strongly correlated with TT and cFT than either WC or BMI. Furthermore, in models of TT and cFT, the addition of Ht to WC resulted in an increase in the magnitude of the regression coefficients for both WC (inverse correlate) and Ht (positive correlate), with the contributions of both WC and Ht both being significant (P<0.05 for all). In conclusion, WHt ratio is the best anthropometric predictor of both TT and cFT in this group of healthy but symptomatic ageing men.
血清睾酮在衰老男性中的下降可能部分受到肥胖的影响；然而，哪种肥胖指标与睾酮水平最密切相关尚不确定。我们研究了与低雄激素血症症状一致但其他方面健康的老年男性的年龄、肥胖和睾酮水平之间的关系。我们对来自社区的年龄≥54 岁的非吸烟男性进行了横断面研究，这些男性没有癌症或严重的疾病。测量身高（Ht）、体重和腰围（WC），并计算体重指数（BMI）和腰高比（WHt）。采集两份早晨血样，用于测量总睾酮（TT）、性激素结合球蛋白（SHBG）和促黄体生成激素（LH）。计算游离睾酮（cFT）。进行多元线性回归分析，以评估它们与肥胖指标的关系。研究了 207 名年龄在 54-86 岁的男性。在单变量分析中，WHt 比与 TT 和 cFT 的相关性强于 WC 或 BMI。此外，在 TT 和 cFT 的模型中，将 Ht 添加到 WC 中会导致 WC（逆相关）和 Ht（正相关）的回归系数的幅度增加，WC 和 Ht 的贡献均具有统计学意义（所有 P<0.05）。总之，在这群健康但有症状的老年男性中，WHt 比是 TT 和 cFT 的最佳人体测量预测指标。
